Boston Biotech Company Introduces “CRISPR 2.0” For The First Time Ever In Patient, Allowing The Ability To Completely Alter People

Those are the words of Yuval Noah Harari, a leading professor at Hebrew University in Israel, and a contributor for the World Economic Forum.

During an interview in 2020 in Davos, Harai stated the following:

The major danger we face is the rise of digital dictatorship which will monitor everyone all the time. This danger can be stated in the following simple equation, which could be the defining equation of life in the 21st century:

B x C x D = AHH

where: B = biological knowledge, C = computing power, D = Data, AHH = Ability to Hack Humans.

If you know enough biological knowledge, and you have enough computing power and data, you can hack my body, my brain, and my life. You can understand me better than I understand myself. You know my personality type, my political views, my sexual preferences. my mental weaknesses, my deepest fears and hopes. You know more about me that I do myself. You can do this to everyone. A system that understands us better than we understand ourselves can predict our feelings and decisions, can manipulate our feelings and decisions, and can ultimately make decisions for us.

In the past, many tyrants and governments wanted to do this, but none of them, not the Gestapo, Stasi, or the KGB, etc. had the biological knowledge, computing power, and data to do this.

But soon a handful of both corporations and governments will be able to systematically hack all the people. We humans should get used to the idea that they are no longer mysterious souls. We are now hackable animals.

All of this, and so many more wild statements such as this, were spoken right in the open for the whole world to see.

https://www.youtube.com/watch?v=eOsKFOrW5h8

https://www.youtube.com/watch?v=8qhZXyZ_kpI

Moreover, in a separate video interview, the scientist reiterated that same message.

Humans are now hackable animals. The idea that humans have this soul or spirit, they have free will and nobody knows what’s happening inside me – so whatever I choose whether in the election or in the supermarket, that’s my free will? That’s over.”

Today, we have the technology to hack human beings on a massive scale. Everything is being digitalized [and] monitored.

These goals are now becoming closer and closer to reality:

Say Hello To Base Editing

The gene-splicing technology CRISPR has now gotten an upgrade and is being touted as being much more effective and precise than its predecessor.

As The Boston Globe put it, ‘scientists are rewriting the code of life with a new technology that promises to cure inherited diseases by precisely correcting genetic typos. Known as base editing, the technology empowers researchers to pick a single letter amongst the three billion that compose the human genome, erase it, and write a new letter in its place.’

Base editing is dubbed by some as “CRISPR 2.0” because it is an improved version of the original CRISPR, that can allow scientists alter all sorts of genes and other bodily functions.

Verve Therapeutics, a biotech company based in Boston, Massachusetts, recently announced that they successfully edited the DNA of a person who had a genetic disposition that caused him to have elevated levels of cholesterol, that could potentially cause heart disease. A gene was edited in the liver that will curtail the accumulation of cholesterol.

We are completely trying to rewrite how this disease is cared for.

Verve chief executive and cofounder Sekar Kathiresan, said calling this a “surgery without a scalpel.”

While CRISPR is certainly a very powerful tool, base editing can do a whole lot more. David Liu is accredited by The Boston Globe for birthing this improved version of CRISPR as far back as 2013, recognizing that CRISPR can turn off specific genes but does not actually fix the problems.

We really need ways to correct genes, not just disrupt them. And that’s where base editing comes in.

Liu said

The Boston Globe wrote:

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Base editing is making its way into studies for other conditions as well. Earlier this year, researchers at University College London quietly began a clinical trial using base editors to engineer immune cell therapies for leukemia — likely the first time base editors were used as part of any experimental medicine. And Cambridge firm Beam Therapeutics plans to use base editors to treat people with genetic blood diseases in a trial that will launch later this year. The firm also has early stage programs for cancer, liver disease, immune disorders, and vision loss.

Liu’s base editors are modified versions of CRISPR that act like molecular erasers and pencils, swapping one of the four bases, or letters, of DNA for another. One version, developed by his postdoctoral researcher Alexis Komor in 2016, converts a C into a T. A second base editor, developed by his graduate student Nicole Gaudelli in 2017, changes an A into a G.

The potential power of that strategy is clear in Verve’s clinical trial. Scientists have discovered multiple genes that raise cholesterol and increase the risk of heart attacks. People with genetic mutations in one of these genes, called PCSK9, have extremely low levels of LDL cholesterol — often called “bad cholesterol” — and are “remarkably protected against heart attack,” Kathiresan said.

Our idea was to develop a gene editing medicine that would mimic the natural situation.

Verve uses base editors to introduce a mutation in the PCSK9 gene of patients with familial hypercholesterolemia. The results in monkeys have been remarkable, lowering levels of LDL cholesterol by about 70 percent after two weeks. The levels remained low for at least two years, Kathiresan said.

This seems like a bigger effect than I would have predicted. Even if it were half as effective, I still think that would be a huge game changer.

Said Dr. Sarah de Ferranti, chief of ambulatory cardiology at Boston Children’s Hospital

Current drugs available for familial hypercholesterolemia lower LDL cholesterol by as much as 50 to 60 percent, but they must be injected once or twice a month, a schedule many patients have a hard time sticking to, said Dr. Gary Balady, director of preventative cardiology at Boston Medical Center.

Having a one-time treatment has the potential to save lots of lives.

The first person dosed in Verve’s trial lives in New Zealand, but the company expects regulators to greenlight the trial in the United States and United Kingdom later this year. Gaudelli, who developed the base editor Verve is using, said seeing her invention in the clinic is the “gift of a lifetime.”

Verve’s therapy is an infusion that edits DNA directly in patients. The other two base editor studies starting this year will edit cells in the lab and reinfuse them into patients. Dr. Waseem Qasim, a professor of cell and gene therapy at the UCL Great Ormond Street Institute of Child Health, has already begun a clinical trial in London using base editors to make three changes that will help immune cells fight relapsed T cell leukemia in children.

Qasim previously developed cell therapies for blood cancers using CRISPR, and he was excited to switch to base editing. Cutting multiple genes at once with CRISPR could cause chromosomes to get jumbled up, he said.

Whether there’s any side effects arising from that or not, we don’t know. But there could be.

Since base editors don’t cut DNA, they should be much safer, he said

Later this year, Beam Therapeutics will use base editors to treat people with sickle cell disease and a related condition called beta thalassemia.

Jennifer Doudna, the University of California Berkeley scientist who co-invented CRISPR in 2012, said that while base editing “works very well in research settings,” and could be fine for disrupting genes, she doesn’t think it currently has the precision needed to correct mutations. Base editors often edit other DNA letters around the single letter that you want to edit, she said.

So that means you end up usually getting more editing than you might want.

The groups developing base editing therapies say they have scoured the genomes of edited cells in the lab to look for any unwanted editing. John Evans, chief executive of Beam Therapeutics, said these off-target edits are predictable and thus largely avoidable. “You can kind of engineer around it,” he said.

Liu hopes the three clinical trials of base editors this year are just the start of many more to come.

It still sounds to me like science fiction that you can go into a patient and make a precise change in the sequence of their genome at a position that would otherwise destine them to suffer from a grievous genetic disease.

To be able to take control of our genomes, to me, is one of the most human things we can do.

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With base editing now clearly being poised to be one of the scientific tools and inventions for the future, it will make other ambitions and desires more easily accomplished.

Last year The WinePress reported on panel discussion by Mattew Liao, Director of Center for Bioethics, and Arthur Zitrin Professor of Bioethics at the New York University School of Global Public Health; who discussed the benefits and needs to gene-edit people so they no longer like to eat meat anymore, because the masses will never be persuaded to fully give it up, so reprogramming them is the answer in their minds, along with other gene changes to make people smaller in the name of reducing carbon emissions.

People eat too much meat, right? If they were to cut down on their consumption of meat it would actually really help the planet. But people are not willing to give up their consumption of meat: some people will be willing to, but other people maybe willing to, but they have a weakness of will. They say, ‘Wow, this steak is too juicy, I can’t do it’ – I’m one of those people.

But here’s the thought, right?: it turns out – we have these intolerance to – like I have a milk intolerance, and some people are intolerant to crayfish, so possibly we can use human engineering to make it the case that we are intolerant to certain kinds of meat, to certain kinds of bovine proteins, and there’s actually analogs of this in life: there’s this thing called the Lonestar Tick where if it bites you, you’ll become allergic to meat.

So, that’s something that we can do through human engineering. We can kinda possibly address really big world problems through human engineering.

It turns out that the larger you are – think of the lifetime greenhouse gas emissions that require – the energy that’s required to transport larger people rather than smaller people.

But, if we’re smaller just by 15 centimeters, right? – I did the math and it’s about mass reduction by about 25%, which is huge. And a hundred years ago we were all on average smaller, exactly 15 centimeters smaller, right?

So think just of the lifetime greenhouse gas emissions if we had smaller children, right? And so that’s something we can do through human engineering.

It gets even better: make the people smaller in order to consume less energy. pic.twitter.com/KD5pjmPptD

— Spinte Crusader (@bitcoincrusader) June 22, 2021

FDA Fast-Tracks Clearance For Gene-Edited CRISPR Cattle For Meat Consumption

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AUTHOR COMMENTARY

[1] Now the Spirit speaketh expressly, that in the latter times some shall depart from the faith, giving heed to seducing spirits, and doctrines of devils; [2] Speaking lies in hypocrisy; having their conscience seared with a hot iron; [3] Forbidding to marry, and commanding to abstain from meats, which God hath created to be received with thanksgiving of them which believe and know the truth.

1 Timothy 4:1-3

Normally when I quote this passage I am usually referencing the prohibition and abstinence of meats – which I report on a lot, and all the lab-grown slop, bugz, and eventual cannibalism – but I have also referenced the searing of the conscience before as well. In my book, “The Lord of Glory: The Definitive Guide to Who God is,” I go into great length to describe and show how the physical heart and mind have spiritual connections to the soul and spirit, and our conscience. To sever and edit our genetic code and organs, the way God uniquely designed us, is being described in 1 Timothy 4. Man’s conscience will be severed and cut, and it will be done via all these drugs and pharmaceuticals, chemicals, mRNA, nanotech and cybernetics, CRISPR, and now you can add base editing to the mix.

Moreover, as noted in that passage, and in this report, this can certainly open up Pandora’s Box as to how the masses will be forced off of eating meats.

Lo, this only have I found, that God hath made man upright; but they have sought out many inventions.

Ecclesiastes 7:29

Of course, most people will not take heed to those warnings, and will fall into this trap soon enough. It begins to put the mark of the beast into greater perspective for the future, and how this will all fit in relative to smart cities, metaverse, 6G, and so forth – things I have reported on substantially.

[16] And he causeth all, both small and great, rich and poor, free and bond, to receive a mark in their right hand, or in their foreheads: [17] And that no man might buy or sell, save he that had the mark, or the name of the beast, or the number of his name. [18] Here is wisdom. Let him that hath understanding count the number of the beast: for it is the number of a man; and his number is Six hundred threescore and six.

Revelation 13:16-18

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[7] Who goeth a warfare any time at his own charges? who planteth a vineyard, and eateth not of the fruit thereof? or who feedeth a flock, and eateth not of the milk of the flock? [8] Say I these things as a man? or saith not the law the same also? [9] For it is written in the law of Moses, Thou shalt not muzzle the mouth of the ox that treadeth out the corn. Doth God take care for oxen? [10] Or saith he it altogether for our sakes? For our sakes, no doubt, this is written: that he that ploweth should plow in hope; and that he that thresheth in hope should be partaker of his hope. (1 Corinthians 9:7-10).

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